Pharmacokinetics and toxicology of therapeutic proteins: Advances and challenges :advances and challenges
To reduce potential toxicity, the positively charged groups on their surface are often modified into neutral or negatively charged components
PubMed Gwyer, D., Wragg, N.M., Wilson, S.L
The 50100mg range appears in protocols because it approximates allometric scaling from effective rodent doses, but rigorous human pharmacokinetic data validating those numbers is sparse
3 Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, 518033, Peoples Republic of China *These authors contributed equally to this work Correspondence: Siping Peng, Email [email protected] Maosheng Lee, Email [email protected] Abstract: Diabetic peripheral neuropathy (DPN) is one of the most common chronic complications of diabetes mellitus
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